光动力学治疗鲜红斑痣(PWS)目前被认为是较为有效的一种新型诊疗技术。治疗过程中光能量在皮肤中的分布情况对理解、预计和改进鲜红斑痣的临床治疗效果有重要的作用。基于人体皮肤的组织结构、鲜红斑痣的病理特征、光在皮肤组织中的传输特性以及皮肤各层的组织光学参数, 建立了一种具有多层组织结构的鲜红斑痣皮肤光学模型, 介绍了该模型中组织光学参数的确定方法。利用蒙特卡罗方法结合临床数据计算了光能量在鲜红斑痣皮肤中随深度的分布, 结果可为临床上如何选择最佳光剂量提供部分参考依据。利用本模型做进一步的详细完整的计算可以为光动力学治疗鲜红斑痣提供理论支持。

Monte Carlo algorithm and Stokes-Mueller formalism are used to simulate the propagation behavior of polarized light in turbid media. The influence of single scattering and multiple scattering on backscattered Mueller matrix in turbid media is discussed. Single and double scattering photons form the major part of backscattered polarization patterns, while multiple scattering photons present more likely as background. Further quantitative analyses show that single scattering approximation and double scattering approximation are quite accurate when discussing the polarization patterns near the incident point.

Single scattering model and Stokes-Mueller formalism are introduced to investigate the influence of glucose on backscattered polarization patterns in turbid media. Glucose molecules rotate the polarization plane and induce changes in backscattered Mueller matrix patterns. Some Mueller matrix elements present higher optical rotation as the concentration of glucose augments. Using image subtraction and integration, linear relationship between low glucose concentration in the physiological range and optical rotation degree can be derived.